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![]() The list of people who could potentially seek immunity in exchange for testimony is long, possibly including former Manafort associates and fellow media strategists who have cooperated with Mueller’s investigation.***TAD DEVINE 2014 emails are evidence in MANAFORT case. Podesta didn’t respond to voicemail and email requests for comment. ![]() Among them is Tony Podesta, according to Fox News host Tucker Carlson. Mueller has offered immunity to five individuals in exchange for testifying against Manafort. It will be Mueller’s first trial since beginning his probe into possible Russian collusion with the Trump campaign. That was before he joined the Trump campaign in early 2016. authorities while earning tens of millions of dollars as a political consultant in Ukraine. Prosecutors will argue that Manafort lied about income and offshore accounts to U.S. ![]() Fabrizio, who was the pollster on President Donald Trump’s campaign, is included in email chains with Manafort and his local fixer Konstantin Kilimnik.įabrizio didn’t respond to a voicemail requesting comment. pollster and strategist at Fabrizio, Lee & Associates, worked for Manafort in Ukraine on 2012 parliamentary elections. It’s also unclear how prosecutors intend to use the documents during the trial or who among the men who sent them might be called as witnesses. It’s unclear what’s in the communications, and there’s no indication of wrongdoing by those who emailed Manafort or his partners. Rabin and Strasberg didn’t respond to requests for comment via LinkedIn. Strasberg worked on the Kerry and Sanders presidential campaigns while Rabin, now at RSH Campaigns, has devised ad campaigns for Democratic candidates for two decades. They worked alongside Devine and Mulvey during successive campaigns in Ukraine. Devine, a long-time consultant for the Democratic Party, also advised Al Gore on his presidential run in 2000 and John Kerry’s bid in 2004.ĭevine and Mulvey weren’t available to comment, according to an assistant in their office.Īlso on the list are emails, memos and invoices from Democratic media consultants Daniel Rabin and Adam Strasberg. The emails run from 2006 through to 2014, after Yanukovych fled to Moscow following protests against his rule. Jurors will see email chains involving Devine, Mulvey, Manafort and his right-hand man at the time, Rick Gates. The exhibits also include documents relating to Manafort’s work with Devine’s partner Julian Mulvey, who was the creative director of Sanders’ TV advertising operation. Years before he became Donald Trump’s campaign chairman, Manafort hired the operatives to go to Ukraine on parliamentary and presidential campaigns for former president Viktor Yanukovych, according to the exhibit list and interviews. consultants across the political spectrum. That raises the prospect that Manafort’s trial could churn up insights about the international work of U.S. Among the hundreds of exhibits are emails and memos between Manafort and several go-to political and advertising strategists of the Democratic Party for two decades, including three others who also worked on Sanders’ 2016 bid. Special Counsel Robert Mueller of documents he could show to the jury that will be selected next week in Alexandria, Virginia. The names appear on a list filed this week by U.S. Several prominent Democrats who once worked with Paul Manafort have been dragged into court filings ahead of his fraud trial, most prominently Tad Devine, the 63-year-old political consultant who ran Bernie Sanders’ presidential campaign. It received mixed reviews from critics and grossed $334 million worldwide. ![]() ![]() The film was released on June 10, 2016, by Lionsgate. Filming began in November 2014 and lasted until May 2015. On July 3, 2013, the film was officially announced to be in development. The plot has the Four Horsemen and their leader Dylan Rhodes recruited by Walter Mabry, a criminal mastermind, to steal a data chip. The film stars an ensemble cast that includes Jesse Eisenberg, Mark Ruffalo, Woody Harrelson, Dave Franco, Daniel Radcliffe, Lizzy Caplan, Jay Chou, Sanaa Lathan, Michael Caine, and Morgan Freeman. It serves as a sequel to 2013's Now You See Me and the second installment in the Now You See Me series. Chu from a screenplay by Ed Solomon and a story by Solomon and Peter Chiarelli. Small wonder that “Now You See Me” plays like a two-hour trailer.Īnd by the time it’s over, you don’t really care who’s responsible…because nobody in this film is the least bit interesting or believeable.Now You See Me 2 (also known as Now You See Me: The Second Act) is a 2016 American heist film directed by Jon M. We’re not talking about a director of much subtlety or intellectual curiosity. The cast members, all of whom have been interesting in other films, are bland here – even reliable old pros like Michael Caine (as the reptilian billionaire who finances the Four Horsemen tour) and Morgan Freeman (as a former stage magician who now specializes in debunking claims of the supernatural and magical).ĭirector Leterrier made his name with the “Transporter” franchise, the Ed Norton “Incredible Hulk” and the execrable “Clash of the Titans” remake. Not the characters, which remain one-dimensional not the talk about magic and illusion, which is of fortune cookie complexity and certainly not the big final reveal, which is underwhelming. Nothing introduced in “Now You See Me” is developed. This isn’t a bad premise, but that’s all it is: A premise. ![]() But how are they supposed to charge performers for a crime that took place on the other side of the planet? Especially when the suspects’ explanation is that “It’s magic”?Īll the frustrated authorities can do is follow the Horsemen to big gigs in New Orleans and NYC and hope to catch them in the act of pulling off another “magical” crime. The French report that the Paris bank has in fact been robbed, and FBI investigator Dylan Rhodes (Mark Ruffalo) and Interpol agent Alma Dray (Melanie Laurent) take the case. On their opening night the Horsemen “teleport” a French vacationer to the vault of his bank in Paris, where millions in Euros are sucked up into an air vent and end up fluttering over the delighted audience back on the Strip. These rivals are recruited by a mysterious, unseen individual to form a big Las Vegas magic act, the Four Horsemen. Merritt (Woody Harrelson) is a mentalist/hypnotist. ![]() Jack (Dave Franco…James’ brother) is an accomplished pickpocket. Henley (Isla Fisher) is an escape artist. Daniel (Jesse Eisenberg) is a cocky card manipulator and illusionist. What they’ve produced is a towering house of cards that any two-year-old could knock over.Īt the outset of Louis Leterrier’s film we’re introduced to four struggling street magicians, each of whom has a magic specialty. It feels like something the screenwriters (Ed Solomon, Boaz Yakin, Edward Ricourt) cooked up on a dare, vying to establish the most outlandish, complicated yarn possible. “Now You See Me” isn’t about the characters and it certainly isn’t about stage magic. The movie starts falling apart as soon as it begins. “NOW YOU SEE ME” My rating: C (Opening wide on May 31)īig, slick and determined to wow us with its amazingness, the magic-themed caper film “Now You See Me” is less a David Copperfield spectacular than a fumbled bit of sleight-of-hand as performed by “Arrested Development’s” Gob Bluth. ![]() So, if you love to stock up on your favorite treats, freeze dried candy is the way to go! You'll never have to say goodbye to your favorite candy again. ![]() Just keep it in a cool, dry place, and you're good to go. The best part? You don't have to worry about refrigeration or any fancy storage techniques. It's like a time capsule of sugary goodness! In fact, freeze dried candy can last up to 25 years without going bad! That means you can stock up on your favorite freeze dried candy flavors and never have to worry about them going bad. So, get ready to treat your taste buds and join the freeze dried candy craze! Longer Shelf Life of Freeze-Dried Candyĭo you ever find yourself throwing away your favorite candy because it went stale? Well, say goodbye to that heartbreak because freeze dried candy has come to save the day!įreeze drying gives candy a fun, new texture and extends its shelf life. ![]() In this article, we'll explore the benefits of eating freeze dried candy and why it's a healthier, tastier, and more fun alternative to your typical candy choices. The longer shelf life, portability and convenience, variety, and no-added preservatives are some of the pros to this tasty version of your favorite goodies. But what exactly is freeze dried candy, and why should you switch from regular candy to this new sensation?įreeze dried candy can be a great alternative to regular candy in many ways. Freeze dried candy is taking the market by storm. ![]() Save workflows as plug-ins to provide simple, customised interfaces to Apple Remote Desktop features. Combine actions with other application actions to create end-to-end solutions. As advised by Tetsujin, the way to overcome this is Apple Remote Desktop. Chain actions together to create powerful system administration workflows. Improved security, with an optional compatibility option to support older clients in the Security tab of the Preferences. Get started immediately with over 40 actions. This update improves the overall stability of Apple Remote Desktop and includes the following specific changes: Computer lists, complete with credentials, can be exported to an encrypted archive and restored to other viewers. 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Apple Remote Desktop is the best way to manage the Mac computers on your network. ![]() The S12 Solutions app works on Android and iOS phones. What phones can be used to access the app? You will be able to return to your Touch ID or pin code as usual once you have added this information. Why is the S12 Solutions app asking me to login using my password instead of my touch ID or pin code?Įvery 3 months, S12 Solutions will ask you to login using your email address and password as part of the app’s security protocol. A verification code will be sent to the email address you entered add this code in to the Verification Confirmation box on the Login page.Click Send Verification Code and keep the Login page open.If you would like to reset a forgotten password, please follow this process: Check your junk email folder in case your Welcome Email has been directed there if you do not have a Welcome Email or you have but it was sent more than 30 days ago and the password has expired, please follow these steps:.If you have never logged in before, follow this process: How do I reset my S12 Solutions password using the website version on my computer? You will then be prompted to reset your password.A verification code will be sent to the email address you entered add this code in to the Verification Confirmation box.Click Send Verification Code and keep the app’s Login page open.Enter the email address you have registered with us when prompted.Scroll down to the bottom of the Login page and click Reset Password.How do I reset my forgotten S12 Solutions password from the app on my phone? ![]() A new Welcome Email will be sent to your email address containing a new temporary password use this password to login.Scroll down to the bottom of the Login page and click on Reset Password.If you do not have a Welcome Email or you do but it was sent more than 30 days ago and so the password has expired, please follow these steps: We recommend that you check your junk folder before resetting your password as sometimes Welcome Emails are directed there instead of your main inbox. If you have never logged in to the S12 Solutions platform before and you cannot find the Welcome Email from that contains your temporary password, you can reset your own password, which prompts a new Welcome Email to be sent to you. FAQs How do I reset my S12 Solutions password from the app on my phone? ![]() ![]() It can be used with all types of projects, including magazines, books and brochures, posters, reports, and reports. This program allows you to combine your photos, graphics, and text to create stunning publishing layouts. This program has been used by thousands of professionals around the world to fulfill the needs of 21st-century designers. ![]() Affinity Publisher was developed with the same vision of renowned photo editing and graphic design apps. The product is free to play and the user has the option to purchase additional features, virtual goods, or services that will enhance the game’s functionality. It allows users to download the game and then play it for free. This license is often used for video games. The new Affinity Publisher software will allow you to create everything, from posters and leaflets to an entire eBook. ![]() It also manages to invent new ways of working, just like Affinity Designer and Affinity Photo. It is an Affinity product, and it delivers what we expect. After creating an account, we will be sent the link to the installer. It does not support INDD files saved by Adobe InDesign CC or IDML from older versions. Affinity Publisher supports the import and export of PDF, PSD, and other graphic and vector formats. It also supports posters, reports, reports, stationery, reports, and other creations. This intuitive app can create beautiful layouts for magazines, books, and brochures. Publish with the most up-to-date technology to enhance your layouts. You can make critical image adjustments right from your document with the help of a variety of non-destructive adjustment layers. You can set overprint controls and add bleed and trim marks. For press-ready output, you can also open, edit, and output PDF/X documents.
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I especially loved the passage covering Los Angeles in 1984 where glitter and glam collided with NWOBHM (New Wave Of British Heavy Metal) on the Sunset Strip where, “By 2 A.M., when the bars close, the Strip resembles an underage, red-light district, all sexes on display, drugs, and backstage access better barter than cash.” Kaye takes you to the streets from the subterranean clubs on Bowery in New York City to downtown Seattle where a new sound combining punk and alternative music emerged. Hes credited with the saying nice guys finish last and it may well be that he. Leo Durocher, as his nickname suggests, was a famously mouthy player who became a celebrated manager for the Dodgers. The narrator depicts everything from the frenzy of a young crowd dancing to a new style of music made just for them courtesy of Alan Freed to the allegiance of four lads from Liverpool that eventually altered and amazed those who tuned into a certain television show. Brooklyn was not outgamed but the Dodgers, to use Lippy Leo Durochers favorite expression, went out to try to catch lightning in a bottle. ![]() Lightning Striking depicts every pivotal moment with care. I’ve had many of these moments in my life and you probably have as well – that’s lightning striking right there. While some of these incidents may have been accidental, it created a spark that made people stop and notice. You will notice that each of these destinations and situations are consequences from what came before them time and time again. to accomplish something extraordinarily difficult achieve rare success: So far we're underdogs this season, and will have to catch lightning in a bottle to make the playoffs. I’ve been struck by lightning many a time, many a place,” he says. “The odds of being struck by lightning are 300,00 to 1. In his newest tome, Lightning Striking: Ten Transformative Moments in Rock and Roll, Kaye vividly illustrates the people, places, and events as if you were looking through his eyes. Kaye was born with, grew up with, and grew old with rock and roll (his words, not mine). He is best known as Patti Smith’s longtime guitarist, collaborator, and friend in addition to being an insightful and inspiring music scribe. Send us feedback about these examples.Lenny Kaye has been a fixture in the music business for decades. These examples are programmatically compiled from various online sources to illustrate current usage of the word 'catch/capture lightning in a bottle.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. 2023 Performing the Ninth the way Beethoven heard it in his head is like trying to catch lightning in a bottle. Dylan Hernández, Los Angeles Times, 5 Mar. 2022 There isn’t a team such as the Milwaukee Bucks or Boston Celtics in the West, which is why there is a greater feeling than usual that a fringe contender can catch lightning in a bottle and reach the NBA Finals. 2023 Newcomer Baker Mayfield will try to catch lightning in a bottle twice when his Los Angeles Rams (4-9) travel to Wisconsin for a game against Aaron Rodgers' Green Bay Packers (5-8). American politician, businessman, and inventor Benjamin Franklin is known for a scientific experiment involving lightning and electricity in which he flew a. 2022 But there's probably enough talent here to catch lightning in a bottle for one season. 2023 Finding another Joe Burrow or Ja’Marr Chase is nearly impossible, but some teams are in better shape than others to capture lightning in a bottle the way Cincinnati did. 2023 For Theroux, a feature-length documentary film is the opposite of that, a way to capture lightning in a bottle, and to freeze the star in time. 2023 Four receivers isn’t enough for an NFL team on Sundays, and the decision comes after an offseason where Indianapolis stockpiled low-cost receivers with some level of experience, hoping to catch lightning in a bottle with one. Recent Examples on the Web Mike Schaller Temple City :: In an effort to catch lightning in a bottle, Steve Ballmer has approved a trade for James Harden that is reminiscent of Arte Moreno’s signing of Albert Pujols. Peptide-MHC binding affinity shapes the TCR repertoire, and the particular set of MHC alleles carried by an individual become a source of TCR repertoire diversity, affecting the susceptibility to particular diseases (reviewed in ). There are thousands of MHC variants (alleles) in the human population, which can differ in their peptide specificity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)Įach human carries up to six class I MHC molecules and up to eight class II molecules. The epitope is shown as red spheres and contacting MHC residues are shown as green spheres, while paratope residues are shown as sticks. B, TCR-peptide-MHC complex for a viral peptide TAX and class I HLA A-0201 (PDB identifier 1BD2). TCR contacting residues are shown as sticks. Epitope residues are shown as dark green spheres. A, A crystal structure of SARS-CoV S protein receptor binding domain (green) bound by a neutralizing antibody (PDB identifier: 2DD8) heavy and light chains are colored (magenta and yellow, respectively). Here, generally “epitope” refers to the antigen-derived peptide and not the MHC contacting residues. TCRs, on the other hand, interact with antigen-derived peptide fragments, which are presented by major histocompatibility complex (MHC) proteins ( Fig. ![]() Much effort has been spent on CDR3 modeling, in particular for soluble BCRs (antibodies).īCRs interact directly with antigens, and we refer to interface residues as “paratope” on the BCR side and “epitope” on the antigen side ( Fig. As a result, CDR3 is the most diverse among the three CDRs. The V(D)J recombination junction, in which random nucleotides may be inserted during the recombination, is located in the third CDR (CDR3). For simplicity, in this review, we focus on a single pair of (light-heavy or alpha–beta) chains.īoth BCRs and TCRs belong to the immunoglobulin-like fold in which the canonical antigen binding site is composed of three loops called “complementarity-determining regions” (CDRs), in each receptor chain. TCRs are composed of a single pair of alpha and beta chains while BCRs contain two pairs of light and heavy chains. However, the observed populations of receptor sequences in a given individual follow a power law, where most sequences appear only at very low frequency and a minority of sequences appear at higher frequencies (see for example for a recent discussion).įor both BCRs and TCRs, V regions consist of two polypeptide chains, referred to as “light” (BCRs) or “alpha” (TCRs) and “heavy” (BCRs) or “beta” (TCRs). The number of possible different BCR or TCR sequence combinations is extremely high, with theoretical estimates in the 10 12–10 18 range. On a cell population level, these processes create a functionally diverse and dynamic set (repertoire) of B and T cells. In addition to V(D)J recombination, BCRs can also undergo subsequent somatic hypermutation (SHM) and clonal selection upon antigen encounter, collectively referred to as “affinity maturation”. ![]() In V(D)J recombination within a given cell, variable (V), diversity (D), and joining (J) segments are selected randomly from among many variants, and joined to make the V (variable) region of a full-length receptor. Together, BCRs and TCRs constitute a unique class of proteins whose coding sequences are arranged combinatorically in a cell-autonomous manner known as V(D)J recombination. We also briefly discuss molecular dynamics in this context.ī cell receptors (BCRs) and T cell receptors (TCRs) are key molecules in adaptive immune response that provide protection to perturbations, both from the outside (e.g. We review downstream analyses, including BCR and TCR epitope prediction, antibody-antigen docking and TCR-peptide-MHC Modeling. After describing the recent sequencing technologies for immune receptor repertoires, we survey structural modeling methods for BCR and TCRs, along with methods for clustering such models. Here, we review recent developments in bioinformatics tools for analysis of BCR and TCR repertoires, with an emphasis on those that incorporate structural features. ![]() Because the repertoires are highly diverse, specialized software methods are needed to extract meaningful information from BCR and TCR sequence data. The analysis of BCR and TCR repertoires plays an important role in both basic immunology as well as in biotechnology. B cell receptors (BCRs) and T cell receptors (TCRs) make up an essential network of defense molecules that, collectively, can distinguish self from non-self and facilitate destruction of antigen-bearing cells such as pathogens or tumors. |
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